Ngokukhula kweminyaka, ukulahleka kwe-peptide, ukunwebeka kodonga lwegazi kuyawohloka, kuthinte ukuzinza komfutho wegazi, i-viscosity yegazi, kulula ukubangela isibindi esinamafutha, i-hyperlipidemia, i-cerebral thrombosis, nokuncipha kwenkumbulo, isiyezi, ukukhohlwa, ukuqwasha.Ukulahlekelwa kwama-peptide kungaholela ekunciphiseni kwamathambo, ukwakheka kwemigodi, nokulahlekelwa kwe-calcium, okubangela ubuhlungu bamathambo namalungu, i-bone spurs, imilenze nezinyawo ezingaguquki, i-osteoporosis, ukuphuka kalula, ukuphulukiswa kwamathambo kancane, nokuncipha kokuqina kwamathambo.