Ukuntuleka kwe-peptide emzimbeni kuzodala ukungatheleleki okuphansi, futhi kulula ukutheleleka, kanye nokufa okuphezulu. Kodwa-ke, ngokuthuthuka okusheshayo kwe-immunology yanamuhla, kancane kancane abantu baye babazi ngobudlelwano phakathi kwezakhi zomzimba kanye nokungavikeleki. Ngokwazi kwethu, ukungondleki kahle kwe-peptide emzimbeni kungadala i-hypoplasia kanye ne-atrophy yezitho zomzimba, futhi kunomphumela wokuvikelwa kokungavikeleki kwamaselula kanye nokuphazamiseka kwamakhalisa.

Ukuvikeleka komzimba kuzoshintsha lapho kuncipha kwe-peptide. Kungaba nezizathu ezimbili:

(1)Ukungondleki kwangempela. Ukudla kuqukethe okuqukethwe okuphansi kwamaprotheni noma ikhwalithi ephansi yamaprotheni, kubangela ukuthola amaprotheni amancane we-peptide.

(2)Ukungondleki kwesibili. Umzimba womuntu uncibilikisa amaprotheni, okungukuthi, amandla okugaya amaprotheni ampofu, futhi ukumuncwa nakho kumpofu. Lokho kusho ukuthi, kungokwesibili kwezinye izifo, okubangela amandla ampofu omzimba ukuhlanganisa ama-peptides, ukumuncwa kabi, ukusetshenziswa okungafanele, noma ukukhishwa okungafanele, noma ukukhishwa ngokweqile.

Ukungondleki nge-Peptide kungukuntuleka okukhulu kokudla okunempilo, okuvezwe e-Emiciation, edema nokukhathala.

(1)I-Equciation ibonakala ngesisindo esibi kakhulu sokulahleka, ukulahleka kwezicubu ezingaphansi, kanye nokulahleka okukhulu kwemisipha yomzimba, njengamathambo abantu.

(2)I-edema ibonakala ngokuchitheka kwemisipha, isibindi esandisiwe, ukuncipha kwesibindi, ukusebenza kwesibindi, ukumelana kwesibindi, ukumelana okuphansi, ukuncishiswa okwengeziwe kanye nokufa kwezifo ezingenamagciwane.

(3)Ukukhathala kubonakaliswa ukozela, ukulala kabi, ukuthambekela kwesifuba, ukuphefumula kwesifuba, ukuphefumula, ukungaphatheki kahle, njll.

Ngokuvamile ukukhuluma, umsebenzi wokuzivikela kwabantu abanokungondleki kwe-peptide kuphansi kunezinga elijwayelekile. Ukusebenza okuthize kungokulandelayo:

I-Thymus ne-lymph node: izitho zokuqala nezicubu ezihlushwa ukungondleki kahle kwe-peptide yiThymus nama-lymph node. Usayizi wethrumnciphisa, isisindo sincishisiwe, umngcele phakathi kwe-cortex ne-medulla akucaci, kanti nenombolo yeseli incishisiwe. Ubungako, isisindo, isakhiwo sezicubu, ukuqina kwesitokisi kanye nokwakheka kwezinsizwa ze-spleen ne-lymph nazo zinezinguquko ezisobala eziwohlokayo. Uma kuhambisana nokutheleleka, izicubu ze-lymphatic zizoncipha kakhulu. Ukuhlolwa kukhombisile ukuthi izicubu zeThymus zingabuyela kokujwayelekile ngemuva kokungezelela ukondleka kwe-peptide ezilwaneni ezintula umsoco.

Ukuzivikela kwamaselula kusho ukungavikeleki okukhiqizwa ama-t lymphocyte. Lapho umsoco we-peptide entula, i-thymus nezinye izicubu ziyancipha futhi ukukhula kwamaseli e-T kuyathinteka. Ukwehla komzimba wokuzivikela kwamaselula akubonakali kuphela njengokuncipha kwenani lama-T cell, kodwa futhi nokungasebenzi kahle.

Ukuzivikela emzimbeni kusho ukungavikeleki okubangelwa yi-B Lymphocytes yangaphakathi. Lapho umzimba womuntu uswele umsoco wamaprotheni we-peptide, cishe awukho ushintsho enanini lamaseli we-B egazini le-peripheral. Izivivinyo ezisebenzayo zikhombise ukuthi kungakhathalekile ukuthi zingakhathazeki ngenxa ye-peptide yokudla okunempilo, ukugxilisa i-serum kuvamile noma kuphakama kancane, ikakhulukazi uma kuhambisana nokutheleleka, ngakho-ke kukhulu umsebenzi wokuvikela ngokumelene nama-antibodies.

Ukugcwalisaindlela yokwenzaInomphumela wokukhuthaza impendulo yokuzivikela, okubandakanya nomphumela ekufakweni kwe-opsonization, okunamathiselwe emzimbeni, i-phagocytosis, ama-chemotaxis amaseli amhlophe egazi nokungathathi hlangothi kwamagciwane. Lapho umsoco wamaprotheni we-peptode entula, inani eliphelele futhi umphelelisi C3 asezingeni elibucayi noma ukwehla, nomsebenzi wabo wehla. Lokhu kungenxa yokuthi izinga lokuhlanganiswa komphelelisi liyancipha. Lapho ukutheleleka kubangela ukubopha okuhlanganisiwe kwe-Antigen, ukusetshenziswa kokukhuphuka kokwenyuka.

Ama-phagocytes: Ezigulini ezinokuntuleka kokudla okunempilo okunamandla kwe-peptide, inani eliphelele lama-neutrophilsna-Imisebenzi yabo ihlala ingashintshiwe. Amakhemikhali amaseli ajwayelekile noma ancipha kancane, futhi umsebenzi we-phagocytic ujwayelekile, kepha amandla okubulala ama-microorganisms agwinywa amaseli abuthakathaka. Uma i-peptide yengezelelwa ngesikhathi, umsebenzi wama-phagocyte angabuyiselwa kancane ngemuva kwamasonto amabili noma amabili.

Amanye amasosha omzimbatUkwehliswa kokukhiqizwa kwe-interferon, njll., kungathinta ukuthambekela komgcini wokutheleleka.